Ligated D-protein and method of identifying compounds that modulate receptor activity

A ligated D-protein is disclosed represented by the formula: R-L-R' wherein: R and R' are D-peptides (amino acid residue sequences consisting essentially of D-amino acids), at least one of R and R' having a length of at least 50 amino acids and L represents a linkage unit for ligating...

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Bibliographische Detailangaben
Hauptverfasser:	KENT, STEPHEN BRIAN HENRY, MILTON, SASKIA CHARLOTTE FLORENCE, MILTON, RAYMOND CECIL DELISLE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A ligated D-protein is disclosed represented by the formula: R-L-R' wherein: R and R' are D-peptides (amino acid residue sequences consisting essentially of D-amino acids), at least one of R and R' having a length of at least 50 amino acids and L represents a linkage unit for ligating R to R', L being selected from the group consisting of thiol ester and selenol ester linkage units. A method is also disclosed of identifying compounds that modulate receptor activity comprising: (a) contacting at least one compound from a chemical library with a D-receptor, and (b) determining said compound's ability to modulate said D-receptor's activity; wherein said compound is not known to inhibit said D-receptor activity prior to said contacting.