Method for measuring interaction between sugar and target

Method for measuring interaction between sugar and target

An improved method for measuring an interaction between sugars and targets by a fluorescence polarization technique is provided. The improvement resides in that the sugars are involved in the form of substantially stable fluorescence-labeled sugars which are obtained by reacting specific groups (e.g...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BURKE, THOMAS J, MIYAMURA, TSUYOSHI, BOLGER, RANDALL E, KATO, IKUNOSHIN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PHYSICS
SUGARS
TESTING
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Beschreibung
Zusammenfassung:An improved method for measuring an interaction between sugars and targets by a fluorescence polarization technique is provided. The improvement resides in that the sugars are involved in the form of substantially stable fluorescence-labeled sugars which are obtained by reacting specific groups (e.g., reducing groups) of the sugars with labeling fluorophores. This method can be used for the screening of sugars, particularly those derived from natural products, having an interaction with targets and the subsequent structural analysis of such sugars, or for the screening of targets having an interaction with specific sugars and the subsequent structural analysis of such targets.