Method for obtaining recombinant surface antigen of hepatitis B virus (HEP B) of higher immunogenic capacity and use thereof in a vaccine preparation

A multi-step process for recovering hepatitis B surface antigen from Pichia pastoris cells containing a gene encoding said hepatitis B surface antigen and having expressed it. The process leads to a high yield of very pure, homogeneous HBsAg in a particulated form having a high immunogenicity, suita...

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Hauptverfasser:	MUZIO, GONZALEZ, VERENA L, HERRERA MARTINEZ, LUIS SATURNINO, DE LA RIVA DE LA RIVA, GUSTAVO ALBERTO, AGRAZ FIERRO, ALBERTO, QUINONES MAYA, YAIR, GARCIA SUAREZ, JOSE, PAEZ MEIRELES, ROLANDO, FONTIRROCHI ESCOBAR, GIUVEL, AYON ZORRILLA, FILIBERTO ROSENDO, BELDARRAIN IZNAGA, ALEJANDRO, DUARTE CANO, CARLOS ANTONIO, IZQUIERDO LOPEZ, GLADYS MABEL, GARCIA PENA, ARNALDO, PENTON ARIAS, EDUARDO, RAMIREZ ALBAJES, VICTORIA, PEREZ SUAREZ, LILIA LUISA, PADRON GONZALEZ, GUILLERMO JULIO, SANTIAGO AVILA, RAMON ALEXIS, DIAZ BETANCOURT, RAUL ENRIQUE, NAZABAL GALVEZ, MARCELO, GONZALEZ GRIEGO, MARTA DE JESUS, RUIZ CRUZ, CARLOS ENRIQUE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A multi-step process for recovering hepatitis B surface antigen from Pichia pastoris cells containing a gene encoding said hepatitis B surface antigen and having expressed it. The process leads to a high yield of very pure, homogeneous HBsAg in a particulated form having a high immunogenicity, suitable for use in vaccine compositions for treating human beings and for use in diagnostic methods.