New nucleotide sequences for the cell cycle regulated expression of structural genes

The invention refers to a nucleic acid construct comprising: a) at least one activator sequence b) at least one promotor module comprising a nucleotide sequence which binds a protein of the E2F family and a protein of the CDF-1 family c) at least one structural gene, wherein said promotor module, co...

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Bibliographische Detailangaben
Hauptverfasser:	SEDLACEK, HANS-HARALD, DR, LIU, NINGSHU, MUELLER, ROLF, DR, ZWICKER, JOERK
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention refers to a nucleic acid construct comprising: a) at least one activator sequence b) at least one promotor module comprising a nucleotide sequence which binds a protein of the E2F family and a protein of the CDF-1 family c) at least one structural gene, wherein said promotor module, comprises at least one nucleotide sequence which is selected from the group consisting of ACTTGGCGGGAGATTTGAAT and GCTTGGCGGGAGGTTTGAAT, a process for the preparation of a pharmaceutical containing said nucleic acid construct for use in treatment of a tumor disease and the protein CDF-1 and its use for the search of modulations of its repressor function.