Sulphonamide derivatives

Sulphonamide derivatives

The present invention provides compounds of the formula: wherein R14 represents a phenyl group which is unsubstituted or substituted by one or two of halogen; nitro; cyano; (1-10C) alkyl; (2-10C)alkenyl; (2-10C)alkynyl; (3-8C)cycloalkyl; halo(1-10C)alkyl; (CH2)zX3R15 in which z is 0 or an integer of...

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Bibliographische Detailangaben
Hauptverfasser: ARNOLD, MACKLIN BRIAN, MATSUMOTO, KEN, ORNSTEIN, PAUL LESLIE, ZIMMERMAN, DENNIS MICHAEL, BAKER, STEPHEN RICHARD, BLEISCH, THOMAS JOHN, SMITH, EDWARD, TIZZANO, JOSEPH PATRICK, CANTRELL, BUDDY EUGENE, ZARRINMAYEH, HAMIDEH, MCKENNON, TRACEY ELAINE, SIMON, RICHARD LEE, BLEAKMAN, DAVID, ESCRIBANO, ANA MARIA
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides compounds of the formula: wherein R14 represents a phenyl group which is unsubstituted or substituted by one or two of halogen; nitro; cyano; (1-10C) alkyl; (2-10C)alkenyl; (2-10C)alkynyl; (3-8C)cycloalkyl; halo(1-10C)alkyl; (CH2)zX3R15 in which z is 0 or an integer of from 1 to 4, X3 represents O, S, NR16, CO, COO, OCO, CONR17, NR18CO, OCONR19, R15 represents hydrogen, (1-10C) alkyl, (3-10C)alkenyl, (3-10C)alkynyl or (3-8C)-cycloalkyl and R16, R17, R18 and R19 each independently represents hydrogen or (1-10C)alkyl, or R15 and R16, R17, R18 or R19 together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl or morpholino group; or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising these compounds.