PROCESS FOR PRODUCING 2-(HALOMETHYL)PHENYLACETIC ACID ESTERS

PROCESS FOR PRODUCING 2-(HALOMETHYL)PHENYLACETIC ACID ESTERS

2-(Halomethyl)phenylacetic acid esters (3) which are useful as intermediates for producing agricultural fungicides are produced efficiently and conveniently by reacting a 3-isochromanone derivative (1) with a hydrogen halide and an alcohol or reacting (1) with a halomethyl alkyl ether and then react...

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Bibliographische Detailangaben
Hauptverfasser: TAKAO, YOSHIHIRO, MATSUZAWA, MASAHUMI, ONO, YUKIO, HIRAI, KENJI, MASUDA, KATSUYUKI, SUGIYAMA, MASAHIDE
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:2-(Halomethyl)phenylacetic acid esters (3) which are useful as intermediates for producing agricultural fungicides are produced efficiently and conveniently by reacting a 3-isochromanone derivative (1) with a hydrogen halide and an alcohol or reacting (1) with a halomethyl alkyl ether and then reacting the product with an alcohol in the presence of a base. The starting compound, 3-isochromanone (1), is produced in good yield by reacting an alpha , alpha '-o-xylene dihalide (4) with carbon monoxide and water in an organic solvent in the presence of a palladium catalyst and an inorganic base and then treating the product with an acid.