Substituted amino acid derivatives

Die Erfindung betrifft mit Kohlenhydraten substituierte Aminosauren der Formel worin die Substituenten die in der Beschreibung angegebene Bedeutung haben, ihre Herstellung durch Mehrkomponentenreaktion und ihre Verwendung. Preparation (A) of oligosaccharide analogues and glycoconjugate analogues comprises (a) allowing carbonyl components, carboxylic acids, amines and isonitriles, some or all of which are glycosylated or substituted by carbohydrate residues, to react together in a solvent; and (b) isolating the product. N-Acylated aminoacid derivatives of formula R3CON(R2)CH(R1)COXR4 (I) and their salts are new. R1, R2 = optionally mono- or poly-unsaturated alkyl or cycloalkyl, optionally mono- or poly- unsaturated or aromatic heterocyclyl or heterocyclyl-alkyl, or aryl or arylalkyl (all optionally substituted) or YR5; R3, R4 = H or as for R1; X = O, NH, N(lower alkyl) or S; Y = -(CH2)n-, -(CH2)nO-, -(CH2)nN(COR6) or -(CH2)nCON(R7)-; R5 = a substituted ring R; R = alkyl, tetrahydrofuranyl, tetrahydropyranyl, lower alkyl-tetrahydrofuryl or lower alkyl-tetrahydropyranyl; R6, R7 = H or lower alkyl; n = 0-3; provided that: (1) at least one Y-R5 is present; and (2) when R2 is glycosyl, then a further Y-R5 is present. Preferably R5 is an acyclic or cyclic carbohydrate residue.