PROCESS FOR THE PREPARATION OF (THIO-)CARBONIC/CARBAMIC ACID 2-PYRROLIDONYL-3-ESTERS, THIO ESTERS AND AMIDES

PROCESS FOR THE PREPARATION OF (THIO-)CARBONIC/CARBAMIC ACID 2-PYRROLIDONYL-3-ESTERS, THIO ESTERS AND AMIDES

A process for the preparation of a compound of general formula II: II wherein R1 is hydrogen, or C1-C10 hydrocarbyl or heterocyclyl having 3 to 8 ring atoms, either of which may optionally be substituted; each R2, R3, R4 and R5 is independently hydrogen or C1-C4 alkyl; A is an optionally substituted...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VOHRA, SHAHEEN, KHATOON, COX, JOHN, MICHAEL, SMITH, STEPHEN, CHRISTOPHER, GILLEN, KEVIN, JAMES, MATTHEWS, IAN, RICHARD, ELLIS, RUSSELL, MARTIN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for the preparation of a compound of general formula II: II wherein R1 is hydrogen, or C1-C10 hydrocarbyl or heterocyclyl having 3 to 8 ring atoms, either of which may optionally be substituted; each R2, R3, R4 and R5 is independently hydrogen or C1-C4 alkyl; A is an optionally substituted aromatic or heteroaromatic ring system; and R21 is hydrogen, halogen, OH or OCONHR1, wherein R1 is as defined above; the process comprising cyclizing a compound of general formula III: are as defined in general formula II and R25 is a leaving group such as a halogen atom; under basic conditions.