Benzothiophene compounds, intermediates, processes, and methods of use

The instant invention provides novel benzothiophene compounds of the formula wherein: R1 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-O(C1-C6 alkyl), -O-CO-Ar in which Ar is optionally substituted phenyl, -O-CO-O-Ar in which Ar is optionally substituted phenyl, or -O-SO2-(C4-C6 alkyl); R2...

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Bibliographische Detailangaben
Hauptverfasser:	CULLINAN, GEORGE JOSEPH, FAHEY, KENNAN JOSEPH
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The instant invention provides novel benzothiophene compounds of the formula wherein: R1 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-O(C1-C6 alkyl), -O-CO-Ar in which Ar is optionally substituted phenyl, -O-CO-O-Ar in which Ar is optionally substituted phenyl, or -O-SO2-(C4-C6 alkyl); R2 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-O(C1-C6 alkyl), -O-CO-Ar in which Ar is optionally substituted phenyl, -O-CO-O-Ar in which Ar is optionally substituted phenyl, -O-SO2-(C4-C6 alkyl), -F, -Cl, or -Br; n is an integer from 3 to 8; R3 and R4 each are independently C1-C4 alkyl, or combine to form, with the nitrogen to which they are attached, piperidinyl, pyrrolidinyl, methylpyrrolidinyl, dimethylpyrrolidinyl, or hexamethyleneimino; with the proviso that when n is 3, then neither R1 nor R2 can be -O-SO2-(C4-C6 alkyl); or a pharmaceutically acceptable salt or solvate thereof.