PROCESS FOR PREPARATION OF PURE CYCLOSPORIN CHROMATOGRAPHICALLY USING AN ELUENT CONSISTING ESSENTIALLY OF HIGH PRESSURE CARBON DIOXIDE

PROCESS FOR PREPARATION OF PURE CYCLOSPORIN CHROMATOGRAPHICALLY USING AN ELUENT CONSISTING ESSENTIALLY OF HIGH PRESSURE CARBON DIOXIDE

PCT No. PCT/FI96/00120 Sec. 371 Date Nov. 12, 1997 Sec. 102(e) Date Nov. 12, 1997 PCT Filed Mar. 1, 1996 PCT Pub. No. WO96/27607 PCT Pub. Date Sep. 12, 1996A process is provided for the preparation of pure cyclosporin which is purified chromatographically from a mixture of different cyclosporin form...

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Hauptverfasser: LUNDELL, JUHANI, SUORTTI, TAPANI, HASE, ANNELI, RUOHONEN, JARKKO, ALKIO, MARTTI, AALTONEN, OLLI
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:PCT No. PCT/FI96/00120 Sec. 371 Date Nov. 12, 1997 Sec. 102(e) Date Nov. 12, 1997 PCT Filed Mar. 1, 1996 PCT Pub. No. WO96/27607 PCT Pub. Date Sep. 12, 1996A process is provided for the preparation of pure cyclosporin which is purified chromatographically from a mixture of different cyclosporin forms and other substances prepared by fermentation. The process comprises feeding a mixture containing a desired form of cyclosporin with an eluent consisting of high pressure carbon dioxide and an adjuvant, into a chromatography column being packed with particles prepared of silica, and recovering from the eluent flow coming out of the chromatography column a fraction which contains the desired cyclosporin form in adequately pure form.