PIPERIDINYL-2-ALKYL SUBSTITUTED LINEAR POLYAMINES FOR THE REDUCTION OF INTRACELLULAR, ENDOGENIC POLYAMINE LEVELS SUCH AS PUTRESCINE, SPERMIDINE AND SPERMINE, AND THEIR IMPACT ON CELL PROLIFERATION

PIPERIDINYL-2-ALKYL SUBSTITUTED LINEAR POLYAMINES FOR THE REDUCTION OF INTRACELLULAR, ENDOGENIC POLYAMINE LEVELS SUCH AS PUTRESCINE, SPERMIDINE AND SPERMINE, AND THEIR IMPACT ON CELL PROLIFERATION

PCT No. PCT/EP96/00898 Sec. 371 Date Sep. 15, 1997 Sec. 102(e) Date Sep. 15, 1997 PCT Filed Mar. 4, 1996 PCT Pub. No. WO96/28425 PCT Pub. Date Sep. 19, 1996The invention relates to compounds of formula (I) (I) wherein either R1 is hydrogen and R2 is lower alkyl lower alkenyl or lower alkynyl, m is 3...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: FREI, JOERG, STANEK, JAROSLAV
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:PCT No. PCT/EP96/00898 Sec. 371 Date Sep. 15, 1997 Sec. 102(e) Date Sep. 15, 1997 PCT Filed Mar. 4, 1996 PCT Pub. No. WO96/28425 PCT Pub. Date Sep. 19, 1996The invention relates to compounds of formula (I) (I) wherein either R1 is hydrogen and R2 is lower alkyl lower alkenyl or lower alkynyl, m is 3 or 4 and n is 2 or 3; or R1 and R2 together are tetrainethylene, m is 3 or 4 and n is 2; or salts thereof. The compounds of formula (I) influence polyamine biosynthesis and have antiproliferative activity as well as an action against protozoans.