Inhibitors and substrates of thrombin

Peptides which act as inhibitors or substrates of thrombin are derived from the formula: Aa1 is wherein Ar1 and Ar2 are the same or different and are selected from naphthyl, thionaphthyl, indolyl and saturated groups corresponding to these, optionally substituted by up to three groups from C1-C3 alk...

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Hauptverfasser:	KAKKAR, VIJAY V, ELGENDY, SAID, M.A, SCULLY, MICHAEL F, CHINO, NAOYASHI, CLAESON, GORAN K, DEADMAN, JOHN J, CHENG, LEIFENG
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Peptides which act as inhibitors or substrates of thrombin are derived from the formula: Aa1 is wherein Ar1 and Ar2 are the same or different and are selected from naphthyl, thionaphthyl, indolyl and saturated groups corresponding to these, optionally substituted by up to three groups from C1-C3 alkyl and C1-C3 alkoxy, L1 and L2 are the same or different and are selected from CH2, CH2-CH2, O-CH2 and S-CH2, or Ar-L is H, diphenylmethyl, fluorenyl or saturated groups corresponding to these, provided that both Ar-L groups are not H; and Aa2 is or its C1-C3 alkyl substituted derivatives, wherein R8 is CH2, CH2-CH2, S-CH2, S-C(CH3)2 or CH2-CH2-CH2, provided that when Aa1 is naphthylalanine Y is C3-C9 alkyl or C5-C10 aryl or C5-C10 alkylaryl optionally substituted by up to three groups selected from hydroxy and C1-C4 alkoxy.