A PROCESS FOR PRODUCING POLYPEPTIDES WITH REDUCED ALLERGENICITY

The invention relates to a process for producing polypeptides with reduced allergenicity, by a) fermenting a microorganism capable of producing said polypeptide, b) recovering said polypeptide in substantially pure form, wherein said microorganism is modified in a manner whereby the expressed polype...

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Bibliographische Detailangaben
Hauptverfasser:	BJORNVAD, MADS, ESKELUND, PRENTO, ANNETTE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	AGRICULTURE ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CANDLES CHEMISTRY COMPOSITIONS THEREOF CONTACT LENSES CULTURE MEDIA DETERGENT COMPOSITIONS DETERGENTS ENZYMOLOGY FATTY ACIDS THEREFROM FISHING FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J FORESTRY HUMAN NECESSITIES HUNTING HYGIENE LAUNDERING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING OPTICS PEST REPELLANTS OR ATTRACTANTS PHYSICS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS RECOVERY OF GLYCEROL RESIN SOAPS SOAP OR SOAP-MAKING SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS SPECTACLES SPIRITS SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURESAS SPECTACLES TEXTILES THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES TRAPPING TREATMENT OF TEXTILES OR THE LIKE TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS,FABRICS, FEATHERS, OR FIBROUS GOODS MADE FROM SUCH MATERIALS USE OF SINGLE SUBSTANCES AS DETERGENTS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a process for producing polypeptides with reduced allergenicity, by a) fermenting a microorganism capable of producing said polypeptide, b) recovering said polypeptide in substantially pure form, wherein said microorganism is modified in a manner whereby the expressed polypeptide molecules self-oligomerize. Further contemplated are a DNA construct comprising genes encoding such polypeptides, a recombinant expression vector or transformation vehicle comprising said DNA construct, a cell harbouring said DNA construct or vector. Further microbially produced polypeptides with reduced allergenicity produced according to the process of the invention and compositions comprising said polypeptides. Finally the invention relates to the use of Zipper domains for reducing allergenicity of polypeptides.