SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula in which each T represents a substituent group; x is 0, 1, or 2; D represents...

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Bibliographische Detailangaben
Hauptverfasser:	BENZ, GUENTER, HANS, HEINZ, HERBERT, COMBS, KERRY, JEANNE, BRITTELLI, DAVID, ROSS, BULLOCK, WILLIAM, HARRISON, WOOD, JILL, ELIZABETH, DIXON, BRIAN, RICHARD, SCHNEIDER, STEPHAN, WILHELM, SCOTT, M, KLUENDER, HAROLD, CLINTON, EUGENE, VANZANDT, MICHAEL, CHRISTOPHER, WOLANIN, DONALD, JOHN
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The presently claimed compounds have the generalized formula in which each T represents a substituent group; x is 0, 1, or 2; D represents delta is 0 or 1; U' represents O, S, or N, with the proviso that when U' is N, then delta =0, and when U' is O or S, then delta =1; R14 is any of a variety of substituent groups; and G represents M, in which M represents -CO2H, -CON(R11)2, or -CO2R12, R11 represents H or an alkyl group, R12 represents an alkyl group, and R13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids; and pharmaceutically acceptable salts thereof.