ANTITUMOR COMPOSITION COMPRISING ASCORBIC ACID AND METAL COMPLEXES OF (NA)PHTHALOCYANINES

The invention pertains to biology and medicine, specifically, to the suppression of malignant tumour growth. The problem addressed by the invention is that of finding more effective and less toxic agents for suppressing tumour growth. The invention in essence proposes the use of a substance consisti...

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Hauptverfasser:	ZHUKOVA, OLGA STEPANOVNA, TRESCHALINA, ELENA MIKHAILOVNA, VOLPIN, MARK EFIMOVICH, NOVODAROVA, GALINA NIKOLAEVNA, LEVITIN, ILIA YAKOVLEVICH, VOROZHTSOV, GEORGY NIKOLAEVICH, KAZACHKINA, NATALYA IVANOVNA, SYRKIN, ANATOLY BORISOVICH, YAKUBOVSKAYA, RAISA IVANOVNA, GERASIMOVA, GALINA KONSTANTINOVNA, KALIA, OLEG LEONIDOVICH, CHISSOV, VALERY IVANOVICH, LUZHKOV, JURY MIKHAILOVICH, LUKIYANETS, EVGENY ANTONOVICH, KRAINOVA, NADEZHDA JURIEVNA
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention pertains to biology and medicine, specifically, to the suppression of malignant tumour growth. The problem addressed by the invention is that of finding more effective and less toxic agents for suppressing tumour growth. The invention in essence proposes the use of a substance consisting of a cobalt or iron complex with substituted phthalocyanines (I) or naphthalocyanines (II) and of a biogenic reducing agent. In the formulae shown, R = COONa, SO3Na, CH2C5H4NCl, CH2(NH2)2SCH2Cl. Use of the proposed agent facilitates effective suppression of a wide range of malignant neoplasms, specifically, suppression of malignant cell proliferation (in vitro), slowing of tumour growth in mice (in vivo), and a significant increase in the life expectancy of the mice by comparison with inter alia the use of a prototype.