Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes

Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes

Preparation of substituted imidazole-4-carboxaldehydes of formula (I) comprises: (a) reacting glycine with imido ester of formula RC(=NH)OR1 (II) to give acid derivatives of formula RC(=NH)NHCH2COOH (III); and (b) reacting (III) with Vilsmeier reagent prepared from a chlorinating agent and a formami...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: STUCKY, GERHARD CHRISTIAN, GRIFFITHS, GARETH JOHN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Preparation of substituted imidazole-4-carboxaldehydes of formula (I) comprises: (a) reacting glycine with imido ester of formula RC(=NH)OR1 (II) to give acid derivatives of formula RC(=NH)NHCH2COOH (III); and (b) reacting (III) with Vilsmeier reagent prepared from a chlorinating agent and a formamide of formula R2R3N-CHO (IV) to give (I). R = H, alkyl, alkenyl, cycloalkyl, aralkyl or aryl; R1 = alkyl; and R2, R3 = 1-4C alkyl or aryl.