Long-lasting release nifedipine preparation

Long-lasting release nifedipine preparation

This invention provides a long-lasting release solid nifedipine preparation which exhibits clinically sufficient effect when administered once per day. ÄConstructionÜ A press coated tablet whose core and shell each contains nifedipine, the dissolution rate of nifedipine from said tablet being (a) in...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TENTER, ULRICH, KANASAKI, HARUO, NISHIOKA, TAKAAKI, OHM, ANDREAS, KURATANI, KENJI, LUCHTENBERG, HELMUT
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This invention provides a long-lasting release solid nifedipine preparation which exhibits clinically sufficient effect when administered once per day. ÄConstructionÜ A press coated tablet whose core and shell each contains nifedipine, the dissolution rate of nifedipine from said tablet being (a) in the dissolution test using a sinker according to method 2 of the dissolution test method as prescribed by the Pharmacopoeia of Japan, after 2 hours 10-40% after 4 hours 30-65% after 6 hours at least 55%, and (b) in the dissolution test according to the disintegration test method as prescribed by the Pharmacopoeia of Japan, after 3 hours 20-45% after 4 hours 30-65%. c