NOVEL CARBAPENEM DERIVATIVES

Novel carbapenem derivatives, represented by the following formula (I), having a substituted or unsubstituted imidazoÄ5,1-bÜthiazolium-6-ylmethyl group at the 2-position are disclosed. The compounds represented by the formula (I) have potent antibacterial activity against a wide spectrum of bacteria...

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Hauptverfasser: ISHII, MIYUKI, AIHARA, KAZUHIRO, TOYOOKA, YUMIKO, ATSUMI, KUNIO, SETSU, FUMIHITO, KANO, YUKO, SASAKI, TOSHIRO, IWAMATSU, KATSUYOSHI, SHIOKAWA, SOHJIRO, TAMURA, ATSUSHI
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creator ISHII, MIYUKI
AIHARA, KAZUHIRO
TOYOOKA, YUMIKO
ATSUMI, KUNIO
SETSU, FUMIHITO
KANO, YUKO
SASAKI, TOSHIRO
IWAMATSU, KATSUYOSHI
SHIOKAWA, SOHJIRO
TAMURA, ATSUSHI
description Novel carbapenem derivatives, represented by the following formula (I), having a substituted or unsubstituted imidazoÄ5,1-bÜthiazolium-6-ylmethyl group at the 2-position are disclosed. The compounds represented by the formula (I) have potent antibacterial activity against a wide spectrum of bacteria from Gram-positive bacteria to Gram-negative bacteria including Pseudomonas aeruginosa and, in addition, have potent antibacterial activity against various beta -lactamase-producing bacteria and MRSA and are very stable against DHP-1.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title NOVEL CARBAPENEM DERIVATIVES
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