POLYMER-CONJUGATED MALONIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS AND DIAGNOSTIC AGENTS

Cpds. of formula (I) are new, with the exception of sialyl Lewis-X and -A, and derivs. of these which contain a N3, NH2 or OH substit. in place of a N-acetyl gp., or contain glycerin in place of fucose: R , R = H, CH2X or CH2O(CH2)mX ; or R +R = a six-membered substd. carbo- or hetero-cycle; R = O,...

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Bibliographische Detailangaben
Hauptverfasser:	KRETZSCHMAR, GERHARD, BARTNIK, ECKART, SCHMIDT, WOLFGANG, TOEPFER, ALEXANDER, HOERSCH, BRIGITTE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS TESTING THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	Cpds. of formula (I) are new, with the exception of sialyl Lewis-X and -A, and derivs. of these which contain a N3, NH2 or OH substit. in place of a N-acetyl gp., or contain glycerin in place of fucose: R , R = H, CH2X or CH2O(CH2)mX ; or R +R = a six-membered substd. carbo- or hetero-cycle; R = O, S, H or CH2OX ; R , R = O- alpha -NANA (where NANA is N-acetylneuraminic acid), O- beta -NANA, OSO3H, or another monobasic acid; R = H, OH or 1-25C alkyl; or R +R = a six-membered substd. carbo- or heterocycle; Y = O- alpha -NANA, O- beta -NANA, OSO3H, or another monobasic acid; Z = a pyranose, a furanose or an open-chain polyalcohol; m, n, p, q = 1-20; X, X , X = H, NH2, COOH, OH, CH2OH, CH2NH, aryl, 1-25C alkyl or CH2O(CH2)qX; X = H, 1-25C alkyl or aryl; or X +X = O or S.