Cyclic peptide antifungal agents

Cyclic peptide antifungal agents

Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I where: R', R", R"', R, R, R, R, R, R, and R are as defined hereinabove; R is each R is independently hydroxy, halo, nitro, amino, trifluoromethyl, C1-C6...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: TURNER, WILLIAM WILSON, BORROMEO, PETER STANLEY
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I where: R', R", R"', R, R, R, R, R, R, and R are as defined hereinabove; R is each R is independently hydroxy, halo, nitro, amino, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy or C1-C6 alkylthio; a is 1, 2, 3 or 4; R is C1-C12 alkyl, C1-C12 alkoxy or -O-(CH2)m-ÄO-(CH2)nÜp-O-(C1-C12 alkyl); m is 2, 3 or 4; n is 2, 3 or 4; and p is 0 or 1; or a pharmaceutically acceptable salt thereof.i