Heterobenzocyclopentane oxazolidinones having antibacterial activity

2-Oxazolidinone derivs. of formula (I) and their tautomers, isomers and salts are new. R1 = N3, OH, OR2, OSO2R3 or NR4R5; R2 = 1-8C acyl or a protecting gp.; R3 = 1-4C alkyl or phenyl opt. substd. by 1-4C alkyl; R4 = H, 3-6C cycloalkyl, phenyl, 1-8C alkyl, 1-8C alkoxy or protecting gp.; R5 = as for...

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Hauptverfasser:	BARTEL, STEPHAN, WERLING, HANS-OTTO, STOLLE, ANDREAS, LABISCHINSKI, HARALD, DR, ENDERMANN, RAINER, WILD, HANNO, RUPPELT, MARTIN, BREMM, KLAUS-DIETER, KROLL, HEIN-PETER, HAEBICH, DIETER, SCHALLER, KLAUS, RIEDL, BERND
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	2-Oxazolidinone derivs. of formula (I) and their tautomers, isomers and salts are new. R1 = N3, OH, OR2, OSO2R3 or NR4R5; R2 = 1-8C acyl or a protecting gp.; R3 = 1-4C alkyl or phenyl opt. substd. by 1-4C alkyl; R4 = H, 3-6C cycloalkyl, phenyl, 1-8C alkyl, 1-8C alkoxy or protecting gp.; R5 = as for R4 or COR6, PO(OR7)(OR8) or SO2R9; R6 = 1-8C alkyl, 2-8C alkenyl (both opt. substd. by CN, halo or CF3), H, opt. halo-substd. 3-6C cycloalkyl, CF3, 1-8C alkoxy, phenyl, benzyloxy, 1-6C thioalkyl, acyl, NR10R11 or 5-membered heteroaryl contg. 1-3 heteroatoms (S, N and/or O), opt. substd. by 1-3C alkyl; R10, R11 = H, phenyl or 1-6C alkyl; R7, R8 = H or 1-4C alkyl; R9 = 1-4C alkyl or phenyl; A = a gp. of formula (a); ring A is opt. substd.; X = CO, CS, SO, SO2, P(OH) or P(O)(OH); Y = O, S or NR13; R12, R13 = CONH2, NH2, NHSO2R, SO2NH2 or S(O)fR (all opt. substd.), 3-pyrrolidinyl, 4- piperidinyl (both opt. N-substd. by benzyl), 5-nitro-2-pyridyl, 2- or 4-pyridyl, COCCl3, 1-6C acyl (opt. substd. by CF3, CCl3, OH or (opt. aryl-substd.) 1-6C alkoxy); R = alkyl, phenyl, benzyl or tolyl; f = 0-2.