DNA ENCODING 1,3-BETA-D GLUCAN SYNTHASE SUBUNITS

PCT No. PCT/US94/11498 Sec. 371 Date Aug. 1, 1996 Sec. 102(e) Date Aug. 1, 1996 PCT Filed Oct. 11, 1994 PCT Pub. No. WO95/10625 PCT Pub. Date Apr. 20, 1995DNA molecules encoding proteins involved in biosynthesis of 1,3-beta-D glucan are identified, cloned, expressed and used in in vitro assays to sc...

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Hauptverfasser: DOUGLAS, CAMERON M, KELLY, ROSEMARIE, FOOR, FORREST, ONISHI, JANET C, SHEI, GAN-JU, REGISTER, ELIZABETH A, RAMADAN, NAASA M, MORIN, NANCY R, MARRINAN, JEAN A, EL-SHERBEINI, MOHAMMED, KAHN, JENNIFER NIELSEN, CLEMAS, JOSEPH, CHREBET, GARY L, PARENT, STEPHEN ARTHUR
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Sprache:eng ; fre ; ger
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Zusammenfassung:PCT No. PCT/US94/11498 Sec. 371 Date Aug. 1, 1996 Sec. 102(e) Date Aug. 1, 1996 PCT Filed Oct. 11, 1994 PCT Pub. No. WO95/10625 PCT Pub. Date Apr. 20, 1995DNA molecules encoding proteins involved in biosynthesis of 1,3-beta-D glucan are identified, cloned, expressed and used in in vitro assays to screen for antifungal compounds, including compounds that affect cell wall biosynthesis. The invention includes but is not limited to the purified DNA molecules, assays employing the DNA molecules, proteins encoded by the DNA molecules, cells expressing the DNA molecules and altered forms of the molecules.