FUSED PYRIDAZINE COMPOUND

FUSED PYRIDAZINE COMPOUND

A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as "cGMP-PDE"). The compounds are useful as preventive and therape...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MATSUKURA, MASAYUKI, SOUDA, SHIGERU, WATANABE, NOBUHISA, KABASAWA, YASUHIRO, ISHIHARA, HIROKI, MIYAZAKI, KAZUKI, TAKASE, YASUTAKA, MIYAKE, KAZUTOSHI, OZAKI, FUMIHIRO, ISHIBASHI, KEIJI, ADACHI, HIDEYUKI, KODAMA, KOHTARO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as "cGMP-PDE"). The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma.