Oxy-phenyl-(phenyl)glycinolamides substituted with a bi-cycle having antiatherosclerotic activity
Carbocyclic and heterocyclic substd. oxyphenylphenyl glycinol-amides (I) and their salts are new: A = naphthyl or a gp. of formulae (a)-(f): R , R = H, halo, OH or 1-4C alkoxy; D, E = H, 3-8C cycloalkyl, N3, OH, halo, alkyl, alkenyl or alkoxy with ≤ 6C, 5- or 6-membered satd. or unsatd. heterocyclyl...
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| creator | MUELLER, ULRICH RADDATZ, SIEGFRIED DR MATZKE, MICHAEL DR BISCHOFF, HILMAR DR DENZER, DIRK DR CONNELL, RICHARD WOHLFEIL, STEFAN DR BEUCK, MARTIN DR GOLDMANN, SIEGFRIED GRUETZMANN, RUDI MOHRS, KLAUS-HELMUT |
| description | Carbocyclic and heterocyclic substd. oxyphenylphenyl glycinol-amides (I) and their salts are new: A = naphthyl or a gp. of formulae (a)-(f): R , R = H, halo, OH or 1-4C alkoxy; D, E = H, 3-8C cycloalkyl, N3, OH, halo, alkyl, alkenyl or alkoxy with ≤ 6C, 5- or 6-membered satd. or unsatd. heterocyclyl contg. 1-3 S, N and/or O; NR R , or NR SO2R ; R -R = H, 1-4C alkyl or Ph; R = 1-4C alkyl, Bz or Ph opt. substd. by 1-4C alkyl; L = bond, or -C(R )(R )-; R = H, OH, OMe or halo, and R = H, OH, halo, alkenyl or alkoxy with ≤ 8C, 3-14C cycloalkyl or cycloalkenyl, 1-8C alkyl opt. substd. by 3-8C cycloalkyl, Ph or tetrahydropyranyl (opt. substd. by halo), CH2SiR R R , or indanyl; or CR R = satd. 5-7 membered carbocyclic ring opt. mono- or di-substd. by 1-4C alkyl; or R +R = O or a gp. of formula (g): R -R = 1-4C alkyl; a = 2-6; the cpds. 2(R*)- and 2(S*)-2-Ä4-(quinolin-2-yl methoxy)-phenylÜ -2-cyclopentylacetic acid (S)-phenyl-glycinolamide are excluded. Also claimed is the treatment of atherosclerosis by admin. of excluded cpds. (I), which are known from EP344519. |
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Also claimed is the treatment of atherosclerosis by admin. of excluded cpds. (I), which are known from EP344519.</description><edition>7</edition><language>eng ; fre ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010307&DB=EPODOC&CC=EP&NR=0716082B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010307&DB=EPODOC&CC=EP&NR=0716082B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MUELLER, ULRICH</creatorcontrib><creatorcontrib>RADDATZ, SIEGFRIED DR</creatorcontrib><creatorcontrib>MATZKE, MICHAEL DR</creatorcontrib><creatorcontrib>BISCHOFF, HILMAR DR</creatorcontrib><creatorcontrib>DENZER, DIRK DR</creatorcontrib><creatorcontrib>CONNELL, RICHARD</creatorcontrib><creatorcontrib>WOHLFEIL, STEFAN DR</creatorcontrib><creatorcontrib>BEUCK, MARTIN DR</creatorcontrib><creatorcontrib>GOLDMANN, SIEGFRIED</creatorcontrib><creatorcontrib>GRUETZMANN, RUDI</creatorcontrib><creatorcontrib>MOHRS, KLAUS-HELMUT</creatorcontrib><title>Oxy-phenyl-(phenyl)glycinolamides substituted with a bi-cycle having antiatherosclerotic activity</title><description>Carbocyclic and heterocyclic substd. oxyphenylphenyl glycinol-amides (I) and their salts are new: A = naphthyl or a gp. of formulae (a)-(f): R , R = H, halo, OH or 1-4C alkoxy; D, E = H, 3-8C cycloalkyl, N3, OH, halo, alkyl, alkenyl or alkoxy with ≤ 6C, 5- or 6-membered satd. or unsatd. heterocyclyl contg. 1-3 S, N and/or O; NR R , or NR SO2R ; R -R = H, 1-4C alkyl or Ph; R = 1-4C alkyl, Bz or Ph opt. substd. by 1-4C alkyl; L = bond, or -C(R )(R )-; R = H, OH, OMe or halo, and R = H, OH, halo, alkenyl or alkoxy with ≤ 8C, 3-14C cycloalkyl or cycloalkenyl, 1-8C alkyl opt. substd. by 3-8C cycloalkyl, Ph or tetrahydropyranyl (opt. substd. by halo), CH2SiR R R , or indanyl; or CR R = satd. 5-7 membered carbocyclic ring opt. mono- or di-substd. by 1-4C alkyl; or R +R = O or a gp. of formula (g): R -R = 1-4C alkyl; a = 2-6; the cpds. 2(R*)- and 2(S*)-2-Ä4-(quinolin-2-yl methoxy)-phenylÜ -2-cyclopentylacetic acid (S)-phenyl-glycinolamide are excluded. 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Also claimed is the treatment of atherosclerosis by admin. of excluded cpds. (I), which are known from EP344519.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Oxy-phenyl-(phenyl)glycinolamides substituted with a bi-cycle having antiatherosclerotic activity |
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