Oxy-phenyl-(phenyl)glycinolamides substituted with a bi-cycle having antiatherosclerotic activity

Carbocyclic and heterocyclic substd. oxyphenylphenyl glycinol-amides (I) and their salts are new: A = naphthyl or a gp. of formulae (a)-(f): R , R = H, halo, OH or 1-4C alkoxy; D, E = H, 3-8C cycloalkyl, N3, OH, halo, alkyl, alkenyl or alkoxy with ≤ 6C, 5- or 6-membered satd. or unsatd. heterocyclyl...

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Hauptverfasser:	MUELLER, ULRICH, RADDATZ, SIEGFRIED DR, MATZKE, MICHAEL DR, BISCHOFF, HILMAR DR, DENZER, DIRK DR, CONNELL, RICHARD, WOHLFEIL, STEFAN DR, BEUCK, MARTIN DR, GOLDMANN, SIEGFRIED, GRUETZMANN, RUDI, MOHRS, KLAUS-HELMUT
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Carbocyclic and heterocyclic substd. oxyphenylphenyl glycinol-amides (I) and their salts are new: A = naphthyl or a gp. of formulae (a)-(f): R , R = H, halo, OH or 1-4C alkoxy; D, E = H, 3-8C cycloalkyl, N3, OH, halo, alkyl, alkenyl or alkoxy with ≤ 6C, 5- or 6-membered satd. or unsatd. heterocyclyl contg. 1-3 S, N and/or O; NR R , or NR SO2R ; R -R = H, 1-4C alkyl or Ph; R = 1-4C alkyl, Bz or Ph opt. substd. by 1-4C alkyl; L = bond, or -C(R )(R )-; R = H, OH, OMe or halo, and R = H, OH, halo, alkenyl or alkoxy with ≤ 8C, 3-14C cycloalkyl or cycloalkenyl, 1-8C alkyl opt. substd. by 3-8C cycloalkyl, Ph or tetrahydropyranyl (opt. substd. by halo), CH2SiR R R , or indanyl; or CR R = satd. 5-7 membered carbocyclic ring opt. mono- or di-substd. by 1-4C alkyl; or R +R = O or a gp. of formula (g): R -R = 1-4C alkyl; a = 2-6; the cpds. 2(R)- and 2(S)-2-Ä4-(quinolin-2-yl methoxy)-phenylÜ -2-cyclopentylacetic acid (S)-phenyl-glycinolamide are excluded. Also claimed is the treatment of atherosclerosis by admin. of excluded cpds. (I), which are known from EP344519.