Oxy-phenyl-(phenyl)glycinolamides substituted with a heterocycle having antiatherosclerotic activity

Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide der Formel (I) werden durch Umsetzung der entsprechenden heterocyclisch substituierten Oxyphenylcarbonsäuren mit Phenylglycinol hergestellt. Die neuen Stoffe eignen sich als Wirkstoffe in Arzneimitteln, insbesondere in Mitteln mit antiatherosklerotischer Wirkung. Formel (I): in welcher A: für Naphthyl oder für einen Rest der Formel Carbocyclic and heterocyclic substd. oxyphenylphenyl glycinol-amides (I) and their salts are new: A = naphthyl or a gp. of formulae (a)-(f): R , R = H, halo, OH or 1-4C alkoxy; D, E = H, 3-8C cycloalkyl, N3, OH, halo, alkyl, alkenyl or alkoxy with ≤ 6C, 5- or 6-membered satd. or unsatd. heterocyclyl contg. 1-3 S, N and/or O; NR R , or NR SO2R ; R -R = H, 1-4C alkyl or Ph; R = 1-4C alkyl, Bz or Ph opt. substd. by 1-4C alkyl; L = bond, or -C(R )(R )-; R = H, OH, OMe or halo, and R = H, OH, halo, alkenyl or alkoxy with ≤ 8C, 3-14C cycloalkyl or cycloalkenyl, 1-8C alkyl opt. substd. by 3-8C cycloalkyl, Ph or tetrahydropyranyl (opt. substd. by halo), CH2SiR R R , or indanyl; or CR R = satd. 5-7 membered carbocyclic ring opt. mono- or di-substd. by 1-4C alkyl; or R +R = O or a gp. of formula (g): R -R = 1-4C alkyl; a = 2-6; the cpds. 2(R*)- and 2(S*)-2-Ä4-(quinolin-2-yl methoxy)-phenylÜ -2-cyclopentylacetic acid (S)-phenyl-glycinolamide are excluded. Also claimed is the treatment of atherosclerosis by admin. of excluded cpds. (I), which are known from EP344519.