ATHEROSCLEROTIC PLAQUE SPECIFIC ANTIGENS, ANTIBODIES THERETO, AND USES THEREOF

The subject invention provides a naturally occurring antigen indicative of the presence of atherosclerotic plaque. The subject invention provides a murine-human chimeric monoclonal antibody which specifically binds to an antigen indicative of the presence of atherosclerotic plaque; and methods and r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	CHEN, FRANCIS W, DITLOW, CHARLES C, CALENOFF, EMANUEL
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES STEROIDS TESTING
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Beschreibung
Zusammenfassung:	The subject invention provides a naturally occurring antigen indicative of the presence of atherosclerotic plaque. The subject invention provides a murine-human chimeric monoclonal antibody which specifically binds to an antigen indicative of the presence of atherosclerotic plaque; and methods and reagents involving the use of the murine-human chimeric monoclonal antibody. The subject invention provides a CDR-grafted antibody; and methods and reagents involving the use of the CDR-grafted antibody. The subject invention provides a surrogate antigen; methods and reagents involving the use of the surrogate antigen, preparation of the surrogate antigen, antibodies generated from the surrogate antigen.