HETEROAROMATIC COMPOUNDS WITH ANTIPSYCHOTIC ACTIVITY

The present invention relates to a group of piperazine and piperidine derivatives of formula (I), wherein Y is a heteroaryl group optionally substituted by one or more halogen, nitro, C1-6alkyl, C1-6alkoxy, aryloxy, arylC1-6alkylenoxy, hydroxy, S(O)nR or S(O)nN(R )2 where n is 0, 1 or 2, CN, CON(R )2, COR , CO2R , CO-aryl, azido, -N(R )2, -NR N(R )2, -NR N = C(R )2, -NR (C = O)CH(N(R )2)R , -NR (C = O)R , NR CO2R , C1-6alkoxycarbonylamino or PhN = N; with the proviso that Y does not include benzisothiazolyls or benzisoxazolyis, V is O or S; Z is C1-8alkylene optionally interrupted by -O- or -S(O)n- where n is 0, 1 or 2, C2-8alkenylene or C2-8alkynylene; X is N, CR or COR ; A is CR or N; B is oxygen, NR or S(O)n, where n is 0, 1 or 2; and R is hydrogen or one or more halogen, hydroxy, nitro, CN, NR 2, C1-6alkoxy, aryloxy, arylC1-6alkylenoxy, or COR , R, R , R , R , R , R , R and R , are each hydrogen or C1-6alkyl; or a salt, solvate, N-oxide or physiologically functional derivative thereof, to processes for their preparation, to pharmaceutical compositions containing them and to their use in therapy, in particular in the treatment of psychotic disorders.