COATED CAPILLARY COLUMNS AND ELECTROPHORETIC SEPARATION METHODS FOR THEIR USE

COATED CAPILLARY COLUMNS AND ELECTROPHORETIC SEPARATION METHODS FOR THEIR USE

Coated capillary electrophoresis columns and methods for their use in electrophoretic separations are disclosed. The coated capillary columns include a length of tubing having an interior surface coated with at least one crosslinked organic multi-valent ionic compound capable of ionic interaction wi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: SHIEH, CHIA-HUI
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Beschreibung
Zusammenfassung:Coated capillary electrophoresis columns and methods for their use in electrophoretic separations are disclosed. The coated capillary columns include a length of tubing having an interior surface coated with at least one crosslinked organic multi-valent ionic compound capable of ionic interaction with charged chemical functionalities on the tubing interior surface. Exemplary columns are prepared by crosslinking a multi-functional amine compound with a diexpoxide, alkylating the crosslinked multi-functional amine compound to form a crosslinked quaternary ammonium compound, and then contacting the interior surface of capillary tubing with the crosslinked quaternary ammonium compound.