PYRIMIDINE COMPOUND

A pyrimidine derivative represented by general formula (II) or (III) and a salt thereof, both having selective acetylcholine esterase inhibitor and type A monoamine oxidase inhibitor effects, thus being useful as antidepressant and senile dementia remedy. In said formulae, R and R represent each H,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	FUJIWARA, HIROSHI, ANPEIJI, SHIGEHARU, KIMURA, TOMIO, KUROKI, YOSHIAKI
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	A pyrimidine derivative represented by general formula (II) or (III) and a salt thereof, both having selective acetylcholine esterase inhibitor and type A monoamine oxidase inhibitor effects, thus being useful as antidepressant and senile dementia remedy. In said formulae, R and R represent each H, halogen, amino, nitro, (un)substituted alkyl, alkoxy or alkoxycarbonyl, provided that R and R may be combined together to represent (un)substituted alkylene; R represents aralkyl or heteroaryl-alkyl; R represents H or acyl; R represents H, OH or alkoxy; R represents H, halogen, alkyl or alkoxy; X represents -CH=, -CH=CH-(CH2)p-, -CH2- or -CH2CH2-(CH2)p-; Y represents =CH-(CH2)p-, -CH2-(CH2)p-, single bond or double bond; p represents 0 or 1; and symbol @ represents either single or double bond.