Novel cephalosporin antibiotics and processes for the reparation thereof

Novel cephalosporin compounds of formula(I): wherein: R is a hydrogen or an amino protecting group; R and R are, independently, a hydrogen or a hydroxy protecting group, or form together a cyclic diol protecting group; R and R are, independently, a hydrogen or a carboxyl protecting group; X and Y ar...

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Bibliographische Detailangaben
Hauptverfasser: LEE, TAE HEE, KIM, SE HO, YANG, DEOG HO, SEO, MI KYEONG, KIM, SAM SIK, KIM, YONG ZU, BANG, CHAN SIK, YEO, JAE HONG, LIM, JONG CHAN, WOO, YOUNG MIN, JEON, JAE HOON, OH, HUN SEUNG
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Novel cephalosporin compounds of formula(I): wherein: R is a hydrogen or an amino protecting group; R and R are, independently, a hydrogen or a hydroxy protecting group, or form together a cyclic diol protecting group; R and R are, independently, a hydrogen or a carboxyl protecting group; X and Y are a nitrogen and a carbon atom, respectively, or a carbon and a nitrogen atom, respectively; R and R are, independently, a hydrogen or an amino, substituted amino, hydroxy, alkoxy, C1-4 alkyl, carboxyl or alkoxy carbonyl group, or jointly form a C3-7 cycloalkyl group together with the carbon to which they are attached, when X and Y are a nitrogen and a carbon, respectively, or R is a hydrogen or an amino group when X and Y are a carbon and a nitrogen, respectively; and Q is =CH- or =N-, or pharmaceutically acceptable non-toxic salts, physiologically hydrolyzable esters, hydrates and solvates and isomers thereof, and isomers thereof possess potent and broad antibacterial activities.