NOVEL N-HYDROXYALKYL-SUBSTITUTED 1,2,3,6-TETRAHYDROPYRIDINE AND PIPERIDINE DERIVATIVES

PCT No. PCT/HU92/00050 Sec. 371 Date Jan. 17, 1995 Sec. 102(e) Date Jan. 17, 1995 PCT Filed Dec. 1, 1992 PCT Pub. No. WO93/11107 PCT Pub. Date Jun. 10, 1993The invention relates to novel N-hydroxy-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives of the formula (I) wherein A, B, D, E...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	CSEHI, ATTILA, SZOMBATHELYI, ZSOLT, CSIZER, EVA, BODO, MIHALY, SZABO, SANDOR, PALOSI, EVA, AGAI-CSONGOR, EVA, CSOMOR, KATALIN, SARKADI, ADAM, KISS, BELA, HARSANYI, KALMAN, GIZUR, TIBOR, KARPATI, EGON, LASZY, JUDIT, BOD, PETER, KAPOLNAS-PAP, MARTA, SZPORNY, LASZL, GERE, ANIK, HEGEDUES, BELA, KALLAY-SOHONYAI, ANNA, LAPIS, ERZSEBET, SZENTIRMAI, ZSOLT
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PCT No. PCT/HU92/00050 Sec. 371 Date Jan. 17, 1995 Sec. 102(e) Date Jan. 17, 1995 PCT Filed Dec. 1, 1992 PCT Pub. No. WO93/11107 PCT Pub. Date Jun. 10, 1993The invention relates to novel N-hydroxy-substituted 1,2,3,6-tetrahydropyridine and piperidine derivatives of the formula (I) wherein A, B, D, E, G, I and R are as defined in the specification, m is 0, 1 or 2, with the proviso that: m is 0 or 2, or both G and I are hydrogen, when A is benzyl or halogen-monosubstituted benzyl group; and m is 1, when A is 2-picolyl, as well as their pharmaceutically acceptable acid addition salts. The compounds of formula (I) are useful for enhancing the tolerance of mammals (including man) against hypoxic and/or ischaemic states as well as for treating the degenerative and functional disturbances arising from hypoxic and/or ischaemic results.