A STRAIN OF STREPTOMYCES AVERMITILIS GLYCOSYLATES AVERMECTIN COMPOUNDS
Avermectin compounds are glycosylated at the 4',13- Or 14a-positions by adding the avermectin compounds to the fermentation medium of a novel strain of Streptomyces avermitilis. The 4'-hydroxy, 13-hydroxy and 14a-hydroxy methyl groups of the avermectin compound are glycosylated with a glyc...
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Zusammenfassung: | Avermectin compounds are glycosylated at the 4',13- Or 14a-positions by adding the avermectin compounds to the fermentation medium of a novel strain of Streptomyces avermitilis. The 4'-hydroxy, 13-hydroxy and 14a-hydroxy methyl groups of the avermectin compound are glycosylated with a glycosyl moiety, specifically an oleandrose group. The new strain offers the added advantage of not producing any C5-O-methylation products. The compounds are potent anthelmintic and antiparasite agents, and compositions for such uses are also disclosed. U.S patent 3950360 to Aoki e &cir& _t &cir& _ a &cir& _1 &cir& _, discloses milbemycin compounds and European patent application 242052 to Rudd e &cir& _t &cir& _ a &cir& _1 &cir& _ discloses nemedectin compounds with a 25-hydroxy group and a 25-unsaturated alkyl group. |
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