DERIVATIVES OF 9-AMINOACRIDINE HAVING PSYCHOTROPIC, ANTIAMNESTIC AND LIPID REGULATING PROPERTIES

DERIVATIVES OF 9-AMINOACRIDINE HAVING PSYCHOTROPIC, ANTIAMNESTIC AND LIPID REGULATING PROPERTIES

New chemical compounds, derivatives of 9-aminoacridine of general formula (I) where R = H, CH3; R = H, CH3, Br; R = H, CH3; R = alkyl-C1-C5, arylmethyl, diethylaminoethyl; X = C = O, CHOH; Y = CH2; X + Y = CH = CH; and their salts with organic and non-organic acids. The desired compounds are obtaine...

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Hauptverfasser: PORTNOV, YURI NIKOLAEVICH, ROBAKIDZE, TATIANA NIKOLAEVNA, TANANOBA, GALINA VASILIEVNA, KOTLOBAI, ANATOLII ALEKSEEVICH, SUCHANOVA, SVETLANA ALEKSEEVNA, KADYSHEVA, LYUBOV VLADISLAVOVNA, PEGANOV, EDUARD MAKSIMOVICH, VORONIN, ANATOLII EVGENIEVICH, GONCHARENKO, SERGEI BORISOVICH, BUROV, YURI VALENTINOVICH, PENKE, ILMAR CHARIEVICH, OSHIS, YANIS FRITSEVICH, PCHELINTSEVA, LIDIYA EVGENIEVNA
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:New chemical compounds, derivatives of 9-aminoacridine of general formula (I) where R = H, CH3; R = H, CH3, Br; R = H, CH3; R = alkyl-C1-C5, arylmethyl, diethylaminoethyl; X = C = O, CHOH; Y = CH2; X + Y = CH = CH; and their salts with organic and non-organic acids. The desired compounds are obtained by interaction of substituted nitriles of antranyl acid with dimedone with subsequent cyclization of intermediate enaminonitriles into corresponding ketones of 9- aminoacridine after the reduction of which and of their derivatives alkylated or aralkylated on the 9-amino group, the corresponding alcohols are obtained, after hydration of which 9-amino-3,4-dihydroacridines are obtained. When experimented on animals, the said derivatives of 9-aminoacridine have shown psychotropic, antiamnestic and lipid regulating properties, as well as a lower toxicity in comparison with known preparations.