PROCESS FOR PRODUCING 17-g(a)-HYDROXY-3-METHOXY-8,14-SECO-1,3,5(10),9(11) ESTRATETRAENE-14-ONE

PCT No. PCT/DE93/00288 Sec. 371 Date Sep. 26, 1994 Sec. 102(e) Date Sep. 26, 1994 PCT Filed Mar. 24, 1993 PCT Pub. No. WO93/20222 PCT Pub. Date Oct. 14, 1993A process for the production of 17 alpha -hydroxy-3-methoxy-8,14-seco-1,3,5 (10),9(11)estratetraen-14-one by fermentation of 3-methoxy-8,14-sec...

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Hauptverfasser: WEBER, ALFRED, VIDIC, HANS-JOERG, KENNECKE, MARIO
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:PCT No. PCT/DE93/00288 Sec. 371 Date Sep. 26, 1994 Sec. 102(e) Date Sep. 26, 1994 PCT Filed Mar. 24, 1993 PCT Pub. No. WO93/20222 PCT Pub. Date Oct. 14, 1993A process for the production of 17 alpha -hydroxy-3-methoxy-8,14-seco-1,3,5 (10),9(11)estratetraen-14-one by fermentation of 3-methoxy-8,14-seco-1,3,5(10),9(11) -estratetraene-14,17-dione with a live culture of Kloeckera magna is described, which is characterized in that the substrate is reacted in the form of a solventless aqueous suspension with an average grain size of 0.2 to 5 mu m.