1H-indole-3-acetamide derivatives as sPLA2 inhibitors

A class of 1H-indole-3-acetamides, represented by the formula (I), and pharmaceutically acceptable salts thereof; is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.

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Bibliographische Detailangaben
Hauptverfasser:	DILLARD, ROBERT DELANE, BACH, NICHOLAS JAMES, DRAHEIM, SUSAN ELIZABETH, SCHEVITZ, RICHARD WALTER, HERMANN, ROBERT BELL
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A class of 1H-indole-3-acetamides, represented by the formula (I), and pharmaceutically acceptable salts thereof; is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.