Method for purification of estramustin phosphate or salt thereof

Method for purification of estramustin phosphate or salt thereof

Crude estramustin phosphate containing a tertiary amine may be purified by dissolving crude estramustin phosphate in a fatty acid ester, adding both methanol or ethanol and water under acidic conditions to precipitate purified estramustin phosphate, and recovering the precipitate. By this method, th...

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Bibliographische Detailangaben
Hauptverfasser: NOROSE, SATORU, OHWAKI, KEIJI, NIINO, HIDEKI
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Zusammenfassung:Crude estramustin phosphate containing a tertiary amine may be purified by dissolving crude estramustin phosphate in a fatty acid ester, adding both methanol or ethanol and water under acidic conditions to precipitate purified estramustin phosphate, and recovering the precipitate. By this method, the tertiary amine liable to be present in the final product can be effectively removed.