Trifluorothymidine derivatives, process for producing the same and anti-cancer agent containing the same

Trifluorothymidine derivatives, process for producing the same and anti-cancer agent containing the same

A thioester derivative of 3'-O-propargyltrifluorothymidine, which is useful as an anti-cancer agent is disclosed. The thioester derivative according to the present invention is represented by the formula (1): (wherein R represents phenyl group, phenyl group substituted with 1 to 5 halogen atoms...

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Bibliographische Detailangaben
Hauptverfasser: SHIMADA, SHIZUO, ISHIBASHI, HIROKI, SOBAJIMA, TAKESHI, TAKEBAYASHI, NOBUO, YANO, OSAMU, FUKAZAWA, NOBUYUKI, EDATSUGI, HAJIME, KAWAUCHI, NOBUYA, 401 MITSUI TOATSU, IWATA, DAIJI
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:A thioester derivative of 3'-O-propargyltrifluorothymidine, which is useful as an anti-cancer agent is disclosed. The thioester derivative according to the present invention is represented by the formula (1): (wherein R represents phenyl group, phenyl group substituted with 1 to 5 halogen atoms, phenyl group substituted with 1 to 5 C1 - C4 alkyl groups, phenyl group substituted with 1 to 5 C1 - C4 alkoxyl groups, phenyl group substituted with 1 to 5 C1 - C4 alkylthio groups, phenyl group substituted with 1 to 5 C1 - C5 alkanoylamino groups, phenyl group substituted with 1 to 5 trifluoromethyl groups, furyl group, thienyl group or pyrrolyl group).