Process of the selective and quantitative removal or preparation of tumor necrosis factor (TNF) and lipopolysaccharides (LPS) of aqueous solutions

For the quantitative selective removal and/or preparative isolation of tumour necrosis factor (TNF) and/or lipopolysaccharides from aqueous liquids, in particular blood, plasma or serum, the aqueous liquid is passed over an adsorption material which consists of a porous support material with, covale...

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Bibliographische Detailangaben
Hauptverfasser:	BOOS, KARL-SIEGFRIED, DR, SEIDEL, DIETRICH, DR, VON DER HAAR, FRIEDRICH, DR
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PEPTIDES PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION THEIR PREPARATION OR CHEMICAL WORKING-UP THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	For the quantitative selective removal and/or preparative isolation of tumour necrosis factor (TNF) and/or lipopolysaccharides from aqueous liquids, in particular blood, plasma or serum, the aqueous liquid is passed over an adsorption material which consists of a porous support material with, covalently bonded thereto, functional groups of synthetic and/or semisynthetic and/or natural polyanion chains, in linear or branched form, and where appropriate the molecules which have been separated chromatographically in this way are eluted from the adsorption material with a sodium chloride solution. An apparatus according to the invention for the extracorporeal removal of tumour necrosis factor and/or lipopolysaccharides (LPS) from aqueous liquids, in particular blood, plasma or serum, consists of a cylindrical housing which is packed with an adsorption material which consists of a porous support material with, covalently bonded thereto, functional groups of synthetic and/or semisynthetic and/or natural polyanion chains, in linear or branched form, and is provided on its ends with lids which each have a central inflow and outflow connector respectively.