Method for the production of recombinant polypeptides bearing epitopes from different hiv isolates, and their uses as immunogens and in the detection of antibodies against hiv

The present invention provides recombinant polypeptides bearing selected epitopes from Human Immunodeficiency Virus (HIV) isolates. The technical aim is to design and obtain, by means of chemical synthesis, genes encoding for a polypeptide composed not only by different HIV epitopes but also includi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	PADRON PALOMARES GABRIEL RAMON, MONTERO RAMOS MARINIEVE, RODRIGUEZ ORTA MARIA DEL CARME, MENENDEZ ALARCON ALFREDO, DUARTE CANO CARLOS A, HERRERA MATINEZ LUIS SATURNINO
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention provides recombinant polypeptides bearing selected epitopes from Human Immunodeficiency Virus (HIV) isolates. The technical aim is to design and obtain, by means of chemical synthesis, genes encoding for a polypeptide composed not only by different HIV epitopes but also including epitopes corresponding to different HIV isolates. Said polypeptides correspond to the general formulae: Where: I. X1 to Xn represent fragments or viral proteins capable of inducing neutralizing antibodies or peptidic fragments capable of stimulating the proliferation and activation of helper T lymphocytes. II. L represents spacer sequence or "linkers" located between two X regions. Said polypeptides are capable of inducing neutralizing antibodies against HIV. Said polypeptides or antibodies generated against it could be useful for the diagnosis, treatment or prevention of AIDS.