1,4-Substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of Alzheimer's disease

Cyclic amines of formula (I) and their salts are new. J = phenyl, pyridyl, pyrazyl, quinolyl, cyclohexyl, quinoxalyl or furyl (all opt. substd.), a monovalent gp. derived from a cyclic amide cpd., lower alkyl, or -CH=CH-R21; R21 = H or lower alkoxycarbonyl; B = (CHR22)r, CO(CHR22)r, NR4-(CHR22)r, CONR5(CHR22)r, CH=CH(CHR22)r, OCOO(CHR22)r, OOCNH(CHR22)r, NHCO(CHR22)r, CH2CONH(CHR22)r, (CH2)2CONH(CHR22)r, CH(OH)(CHR22)r, (CH-CH=CH)b-, CH(CH2)c, =(CH-CH)d=, COCH=CHCH2, COCH2CH(OH)CH2, H(CH3)CONHCH2, CH=CHCONH(CH2)2, NH, O, S, dialkylaminoalkylcarbonyl or lower alkoxycarbonyl; R4 = H, lower alkyl, acyl, lower alkylsulphonyl, opt. substd. phenyl or opt. substd. benzyl; R5 = H, lower alkyl or phenyl; r = 0-10; R22 = independently H or CH3, b = 1-3; c = 0-9; d = 0-5; T = N or C; Q = N, C or N(O); q = 1-3; k = H, opt. substd. phenyl, aralkyl opt. substd. on the phenyl, cynnamyl, lower alkyl, pyridylmethyl, cycloalkylalkyl, adamantanemethyl, furylmethyl, cycloalkyl, lower alkoxycarbonyl or acyl; and the dotted line indicates an optional double bond.