Fumaric acid salts of quinoline derivatives to overcome MDR in cancer treatment

Fumaric acid salts of quinoline derivatives to overcome MDR in cancer treatment

Compounds having an activity to stimulate the carcinostatic effect of carcinostatic agents, which can be expressed by the following general formula (1): in which A is (in which R1, R2 and R3 are each independent and represent a hydrogen atom or a phenyl group) are made into fumarates so as to improv...

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Bibliographische Detailangaben
Hauptverfasser: KAWAI, YUKICHI, SUZUKI, TUNEJI, YANO, OSAMU, FUKAZAWA, NOBUYUKI, OTSUKA, KENGO, IWATA, DAIJI
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds having an activity to stimulate the carcinostatic effect of carcinostatic agents, which can be expressed by the following general formula (1): in which A is (in which R1, R2 and R3 are each independent and represent a hydrogen atom or a phenyl group) are made into fumarates so as to improve their oral absorbability and solubility in water without interfering with their effects.