LIPOSOME EXTRUSION PROCESS

A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film under pressure is disclosed. In a preferred embodiment, the porous film is a branched type anodic aluminum oxide porous film. The process produces a population of liposomes substantially free of l...

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Bibliographische Detailangaben
Hauptverfasser:	THIES, ROBERT, L, PORTNOFF, JOEL, B, COE, ROYDEN, M
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film under pressure is disclosed. In a preferred embodiment, the porous film is a branched type anodic aluminum oxide porous film. The process produces a population of liposomes substantially free of liposomes above a pre-determined maximum size useful in administering drugs or other bioactive agents, such as in the treatment of cancer or AIDS-related illnesses. Also disclosed for carrying out the method is an apparatus comprising one or more filter assemblies for holding the aluminum oxide porous film in operational configuration (33), a pressurized supply vessel for supplying the suspension of liposomes under pressure to filter assemblies (31), and a receiving vessel for receiving the filtrate from the filter assemblies (32).