Process for the Preparation of Water-Soluble Camptothecin Analogues, as well as the compounds 10-Hydroxy-11-C(1-6)-alkoxycamptothecin

A process for the preparation of water soluble camptothecin analogs, including methods for the preparation of intermediates thereof, and the compounds prepared by said process. Water soluble camptothecin analogs are prepared which may be used for inhibiting the growth of tumor cells sensitive to suc...

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Hauptverfasser: MASTROCOLA, ANTONIETTA ROSE, BURK, PATRICK LEE, WOOD, JEFFERY LEE, MELLINGER, MARK, FORTUNAK, JOSEPH MARIAN
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:A process for the preparation of water soluble camptothecin analogs, including methods for the preparation of intermediates thereof, and the compounds prepared by said process. Water soluble camptothecin analogs are prepared which may be used for inhibiting the growth of tumor cells sensitive to such analogs.