PROCESS FOR PREPARING 2-METHYL-3,5-DIALKYLPYRIDINES BY DEALKYLATION WITH SULFUR

PROCESS FOR PREPARING 2-METHYL-3,5-DIALKYLPYRIDINES BY DEALKYLATION WITH SULFUR

A process for dealkylating the 2-position on a trisubstituted pyridine derivative having the formula where R1 is a straight chain alkyl group from about C2-C5 and where R2 and R3 are alkyl, aryl or aralkyl groups up to about C10, comprising the step of reacting said pyridine derivative at reflux wit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: GOE, GERALD, L
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for dealkylating the 2-position on a trisubstituted pyridine derivative having the formula where R1 is a straight chain alkyl group from about C2-C5 and where R2 and R3 are alkyl, aryl or aralkyl groups up to about C10, comprising the step of reacting said pyridine derivative at reflux with excess sulfur. Of particular note is the preparation of 2,3,5-trimethylpyridine including the initial preparation of its 2-ethyl precursor by the Chichibabin reaction of propionaldehyde and ammonia.