TETRAHYDROPROTOBERBERINE QUATERNARY AMMONIUM COMPOUNDS AND THE PROCESS FOR PREPARING THEREOF

A tetrahydroprotoberberine quaternary ammonium compound represented by the general formula: R,R',X are as defined in the specification. Protoberberine is reduced by potassium borohydride to tetrahydroprotoberberine(I). Tetrahydroprotoberberine quaternary ammonium compounds are prepared by react...

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Hauptverfasser: ZHANG, CAN, PENG, SIXUN, WANG, YOUQUN, YU, FENG, HUANG, ZHENYA, HUANG, WENGLONG, DAI, DEZAI
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creator ZHANG, CAN
PENG, SIXUN
WANG, YOUQUN
YU, FENG
HUANG, ZHENYA
HUANG, WENGLONG
DAI, DEZAI
description A tetrahydroprotoberberine quaternary ammonium compound represented by the general formula: R,R',X are as defined in the specification. Protoberberine is reduced by potassium borohydride to tetrahydroprotoberberine(I). Tetrahydroprotoberberine quaternary ammonium compounds are prepared by reaction of tetrahydroprotoberberine with halohydrocarbon in acetone or ethanol. These compounds can suppress arrhythmia and ventricular fibrillation, protect myocardial ischemia, and can be conveniently orally administered.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title TETRAHYDROPROTOBERBERINE QUATERNARY AMMONIUM COMPOUNDS AND THE PROCESS FOR PREPARING THEREOF
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