TETRAHYDROPROTOBERBERINE QUATERNARY AMMONIUM COMPOUNDS AND THE PROCESS FOR PREPARING THEREOF

A tetrahydroprotoberberine quaternary ammonium compound represented by the general formula: R,R',X are as defined in the specification. Protoberberine is reduced by potassium borohydride to tetrahydroprotoberberine(I). Tetrahydroprotoberberine quaternary ammonium compounds are prepared by react...

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Bibliographische Detailangaben
Hauptverfasser:	ZHANG, CAN, PENG, SIXUN, WANG, YOUQUN, YU, FENG, HUANG, ZHENYA, HUANG, WENGLONG, DAI, DEZAI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A tetrahydroprotoberberine quaternary ammonium compound represented by the general formula: R,R',X are as defined in the specification. Protoberberine is reduced by potassium borohydride to tetrahydroprotoberberine(I). Tetrahydroprotoberberine quaternary ammonium compounds are prepared by reaction of tetrahydroprotoberberine with halohydrocarbon in acetone or ethanol. These compounds can suppress arrhythmia and ventricular fibrillation, protect myocardial ischemia, and can be conveniently orally administered.