Process to isolate carbacephem intermediates

Process to isolate carbacephem intermediates

A process for isolating a beta -lactam compound with about 100% enantiomeric purity, of the formula where R1 is CH3, t-C4H9, C6H5CH2O, C6H5, C6H5OCH2 or C6H5CH2; from a haloalkane solvent, comprising diluting the solution with methyl t-butyl ether or methanol to precipitate the product. The products...

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Bibliographische Detailangaben
Hauptverfasser: STASZAK, MICHAEL ALEXANDER, LUKE, WAYNE DOUGLAS, LEVY, JEFFREY NEAL, DOECKE, CHRISTOPHER WILIAM
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process for isolating a beta -lactam compound with about 100% enantiomeric purity, of the formula where R1 is CH3, t-C4H9, C6H5CH2O, C6H5, C6H5OCH2 or C6H5CH2; from a haloalkane solvent, comprising diluting the solution with methyl t-butyl ether or methanol to precipitate the product. The products thus obtained are key intermediates in the synthesis of antibiotic agents. The process is appropriiate for large scale production.