NAPHTHOIC ACID DERIVATIVE

A naphthoic acid derivative represented by the following general formula or a salt thereof: wherein R1, R2 and R3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, a hydroxy-lower alkyl group, a lower alkox...

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Hauptverfasser: HIGASHIDE, YASUSHI, NISHIMURA, MASATO, FUJI REBIO HACHIOJIRYO, SEKINE, YASUO, KOJIMA, ERI, YAMAURA, TETSUAKI, EMOTO, YASUKO
Format: Patent
Sprache:eng
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Zusammenfassung:A naphthoic acid derivative represented by the following general formula or a salt thereof: wherein R1, R2 and R3 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, a lower alkanoyloxy group, a hydroxy-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkanoyloxy-lower alkyl group or an aralkyloxy group; R4 is a hydrogen atom or a lower alkyl group; R5 is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaromatic group; X is a group a cycloalkylene group, a bivalent nitrogen-containing heterocyclic group, or a group -R8- NH- or -NH-R8, where R6 and R7 are each a hydrogen atom or a lower alkyl group and R8 is a cycloalkylene group, or R6 and R7, together with R4, may form an alkylene group of 1-3 carbon atoms; Y is -S(O)p-, -(CH2)n- or -O-; Z is a substituted or unsubstituted alkylene group or a single bond; l is an integer of 0-4; m is an integer of 0-8; n is 0 or 1; p is an integer of 0-2; and g is 0 or 1. The compound is useful as an antiallergic agent.