Cytotoxic N,N'-bis (succinyl-peptide-) derivatives of 1,4-bis (aminoalkyl)-5,8-dihydroxyanthraquinones and antibody conjugates thereof

Cytotoxic N,N'-bis (succinyl-peptide-) derivatives of 1,4-bis (aminoalkyl)-5,8-dihydroxyanthraquinones and antibody conjugates thereof

The present invention is concerned with novel N,N'-bis(succinyl-peptide)-derivatives of 1,4-bis(aminoalkyl)-5,8-dihydroxyanthraquinones and the corresponding antibody conjugates thereof each of which have potential use in the treatment of human carcinomas.

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Bibliographische Detailangaben
Hauptverfasser: UPESLACIS, JANIS, CROCKATT, LINDA H, SASSIVER, MARTIN LEON, FIELDS, THOMAS LYNN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention is concerned with novel N,N'-bis(succinyl-peptide)-derivatives of 1,4-bis(aminoalkyl)-5,8-dihydroxyanthraquinones and the corresponding antibody conjugates thereof each of which have potential use in the treatment of human carcinomas.